Paramedics received a record number of calls during December, with Christmas parties and falling temperatures contributing to the amount.
From December 10 to 17, the East of England Ambulance NHS Trust responded to 19,529 calls.
Neil Storey, director of operations, said: "999 is really for serious medical emergencies so other incidents will be prioritised accordingly.
"People can help themselves have an enjoyable night and stay well. A party is no fun when it ends with a stay in A&E and all it requires to have a good night is to plan ahead for transport home, look after your friends and be conscious of how much you’re drinking."